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Metabolic phenotypes and vitamin D response in the critically ill: A metabolomic cohort study.

Clinical nutrition (Edinburgh, Scotland) - 1 Nov 2024

Kobayashi Hirotada, Amrein Karin, Mahmoud Sherif H, Lasky-Su Jessica A, Christopher Kenneth B

Abstract excerpt

BACKGROUND & AIMS: Although vitamin D deficiency is common in critically ill patients, randomized controlled trials fail to demonstrate benefits of supplementation. We aimed to identify distinct vitamin D3 responsive metabolic phenotypes prior to trial intervention of high-dose vitamin D3 by applying machine learning clustering method to metabolomics data from the Correction of Vitamin D Deficiency in Critically...

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PMID: 39307095
DOI: 10.1016/j.clnu.2024.09.030

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