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Article

Pharmacometabolomics of l-carnitine treatment response phenotypes in patients with septic shock.

Annals of the American Thoracic Society - 1 Jan 2015

Puskarich Michael A, Finkel Michael A, Karnovsky Alla, Jones Alan E, Trexel Julie, Harris Brooke N, Stringer Kathleen A

Abstract excerpt

RATIONALE: Sepsis therapeutics have a poor history of success in clinical trials, due in part to the heterogeneity of enrolled patients. Pharmacometabolomics could differentiate drug response phenotypes and permit a precision medicine approach to sepsis. OBJECTIVES: To use existing serum samples from the phase 1 clinical trial of l-carnitine treatment for severe sepsis to metabolically phenotype l-carnitine...

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Identifiers

PMID: 25496487
DOI: 10.1513/AnnalsATS.201409-415OC
PMCID: PMC4342803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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