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Molecular basis of CX-5461-induced DNA damage response in primary vascular smooth muscle cells

30 Aug 2024

Abstract excerpt

Our previous studies have shown that the novel selective RNA polymerase I inhibitor CX-5461 suppresses proliferation of vascular smooth muscle cells, mainly by inducing DNA damage response (DDR), including activations of ataxia telangiectasia mutated (ATM)/ATM and Rad3-related (ATR) and p53. Currently, there is no information about the molecular mechanism(s) underlying CX-5461-induced DDR in vascular cells, while...

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PMID: 39296007
DOI: 10.1016/j.heliyon.2024.e37227

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