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Article

The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson’s disease

18 Sept 2024

Abstract excerpt

BACKGROUND: Overactivated microglia are a key contributor to Parkinson's disease (PD) by inducing neuroinflammation. CD200R1, a membrane glycoprotein mainly found on microglia, is crucial for maintaining quiescence with its dysregulation linked to microglia's abnormal activation. We and other groups have reported a decline in CD200R1 levels in several neurological disorders including PD. However, the mechanism...

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PMID: 39294682
DOI: 10.1186/s12974-024-03231-3

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