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Article

Identification of the CD200R1 promoter and the association of its polymorphisms with the risk of Parkinson's disease.

European journal of neurology - 1 Jul 2020

Lin S, He L, Shen R, Fang F, Pan H, Zhu X, Wang M, Zhou Z, Liu Z, Wang X, Fang S, Sun X, Wang Y, Chen S, Ding J

Abstract excerpt

BACKGROUND AND PURPOSE: Neuroinflammation is known to be involved in the pathogenesis of Parkinson's disease (PD). Abnormal activation of microglia plays a key role in this pathological process. CD200R1 is a membrane glycoprotein that is expressed primarily on myeloid cells including microglia and is involved in the maintenance of microglia in a stationary state. Our previous study reported that the regulation of...

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PMID: 32190938
DOI: 10.1111/ene.14224

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