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Article

Crosstalk between FTH1 and PYCR1 dysregulates proline metabolism and mediates cell growth in KRAS-mutant pancreatic cancer cells.

Experimental & molecular medicine - 1 Sept 2024

Park Ji Min, Su Yen-Hao, Fan Chi-Shuan, Chen Hsin-Hua, Qiu Yuan-Kai, Chen Li-Li, Chen Hsin-An, Ramasamy Thamil Selvee, Chang Jung-Su, Huang Shih-Yi, Chang Wun-Shaing Wayne, Lee Alan Yueh-Luen, Huang Tze-Sing, Kuo Cheng-Chin, Chiu Ching-Feng

Abstract excerpt

Ferritin, comprising heavy (FTH1) and light (FTL) chains, is the main iron storage protein, and pancreatic cancer patients exhibit elevated serum ferritin levels. Specifically, higher ferritin levels are correlated with poorer pancreatic ductal adenocarcinoma (PDAC) prognosis; however, the underlying mechanism and metabolic programming of ferritin involved in KRAS-mutant PDAC progression remain unclear. Here, we...

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Identifiers

PMID: 39294443
DOI: 10.1038/s12276-024-01300-4
PMCID: PMC11447051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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