Article
Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.
Cell reports - 20 Mar 2018
Hollinshead Kate E R, Munford Haydn, Eales Katherine L, Bardella Chiara, Li Chunjie, Escribano-Gonzalez Cristina, Thakker Alpesh, Nonnenmacher Yannic, Kluckova Katarina, Jeeves Mark, Murren Robert, Cuozzo Federica, Ye Dan, Laurenti Giulio, Zhu Wei, Hiller Karsten, Hodson David J, Hua Wei, Tomlinson Ian P, Ludwig Christian, Mao Ying, Tennant Daniel A
Abstract excerpt
Since the discovery of mutations in isocitrate dehydrogenase 1 (IDH1) in gliomas and other tumors, significant efforts have been made to gain a deeper understanding of the consequences of this oncogenic mutation. One aspect of the neomorphic function of the IDH1 R132H enzyme that has received less attention is the perturbation of cellular redox homeostasis. Here, we describe a biosynthetic pathway exhibited by...
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