Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrating amyloid imaging and genetics for early risk stratification of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2024

He Bing, Wu Ruiming, Sangani Neel, Pugalenthi Pradeep Varathan, Patania Alice, Risacher Shannon L, Nho Kwangsik, Apostolova Liana G, Shen Li, Saykin Andrew J, Yan Jingwen

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) initiates years prior to symptoms, underscoring the importance of early detection. While amyloid accumulation starts early, individuals with substantial amyloid burden may remain cognitively normal, implying that amyloid alone is not sufficient for early risk assessment. METHODS: Given the genetic susceptibility of AD, a multi-factorial pseudotime approach was proposed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Apolipoprotein E4

Share to Cognitive Dysfunction

Share to Early Diagnosis

Share to Positron-Emission Tomography

Share to Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 39285750
DOI: 10.1002/alz.14244
PMCID: PMC11567859

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrating amyloid imaging and genetics for early risk stratification of Alzheimer's disease.PMID 39285750Read ↗

Addition of Genetics to Quantitative MRI Facilitates Earlier Prediction of Dementia: A Non-invasive Alternative to Amyloid MeasuresSemantic proximity Read ↗

Using Multi-Scale Genetic, Neuroimaging and Clinical Data for Predicting Alzheimer's Disease and Reconstruction of Relevant Biological Mechanisms.Semantic proximity Read ↗

Endophenotype-based polygenic risk scores: Prediction of biomarker and clinical progression and dementiaSemantic proximity Read ↗

Computational Risk Stratification of Preclinical Alzheimer’s in Younger AdultsSemantic proximity Read ↗

An Integrative Multimodal Model for Early Diagnosis of Dementia and Differential Diagnosis of Alzheimer’s Disease Using Neuroimaging, Polygenic Risk, and Cognitive AssessmentsSemantic proximity Read ↗

Effect of Pathway-specific Polygenic Risk Scores for Alzheimer’s Disease (AD) on Rate of Change in Cognitive Function and AD-related Biomarkers among Asymptomatic IndividualsSemantic proximity Read ↗

Multimodal Integration of Alzheimer's Plasma Biomarkers, MRI, and Genetic Risk for Individual Prediction of Cerebral Amyloid BurdenSemantic proximity Read ↗

Towards cascading genetic risk in Alzheimer's disease.Semantic proximity Read ↗

Multi-domain AD risk burden and plasma biomarkers in cognitively unimpaired adultsSemantic proximity Read ↗

Polygenic Risk Scoring is an Effective Approach to Predict Those Individuals Most Likely to Decline Cognitively Due to Alzheimer's DiseaseSemantic proximity Read ↗

Genetic study of multimodal imaging Alzheimer's disease progression score implicates novel loci.Semantic proximity Read ↗

Utility of an Alzheimer’s Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer’s Disease: A Prospective Longitudinal StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.