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Article

Genetic variants associated with white blood cell count amongst individuals with sickle cell disease.

British journal of haematology - 1 Nov 2024

Cintho Ozahata Mina, Guo Yuelong, Gomes Isabel, Malta Barbara, Belisário André, Amorim Luiz, Teles Dahra, Park Miriam, Kelly Shannon, Sabino Ester C, Page Grier P, Custer Brian, Dinardo Carla L

Abstract excerpt

BACKGROUND: Sickle cell disease (SCD) is a Mendelian disorder characterized by a point mutation in the β-globin gene that leads to sickling of erythrocytes. Several studies have shown that absolute neutrophil count is strongly associated with clinical severity of SCD, suggesting an apparent role of white blood cells (WBC) in SCD pathology. However, the mechanism by which genetic variants lead to WBC count...

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Identifiers

PMID: 39279196
DOI: 10.1111/bjh.19758
PMCID: PMC11568933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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