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Article

Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis.

Cell reports. Medicine - 16 Jul 2024

Poch Tobias, Bahn Jonas, Casar Christian, Krause Jenny, Evangelakos Ioannis, Gilladi Hilla, Kunzmann Lilly K, Laschtowitz Alena, Iuso Nicola, Schäfer Anne-Marie, Liebig Laura A, Steinmann Silja, Sebode Marcial, Folseraas Trine, Engesæter Lise K, Karlsen Tom H, Franke Andre, Hubner Norbert, Schlein Christian, Galun Eithan, Huber Samuel, Lohse Ansgar W, Gagliani Nicola, Schwinge Dorothee, Schramm Christoph

Abstract excerpt

Primary sclerosing cholangitis (PSC) is an immune-mediated liver disease of unknown pathogenesis, with a high risk to develop cirrhosis and malignancies. Functional dysregulation of T cells and association with genetic polymorphisms in T cell-related genes were previously reported for PSC. Here, we genotyped a representative PSC cohort for several disease-associated risk loci and identified rs56258221...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Basic-Leucine Zipper Transcription Factors
Share to CD4-Positive T-Lymphocytes
Share to Cholangitis, Sclerosing
Share to Genetic Predisposition to Disease
Share to MicroRNAs
Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 38901430
DOI: 10.1016/j.xcrm.2024.101620
PMCID: PMC11293351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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