Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of genetic mutations in intrahepatic cholestasis of pregnancy

1 Sept 2020

Abstract excerpt

OBJECTIVE: Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder of pregnancy characterized by pruritus, elevated liver enzymes and fasting serum bile acids. Genetic predisposition has been suggested to play a role in its etiology and mutations in the ATP8B1(OMIM ∗602397) (FIC1), ABCB11(OMIM ∗603201) (BSEP), and ABCB4(OMIM ∗171060) (MDR3) genes have been implicated. In the present study, we aimed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Liver Diseases and Immunity
Share to Liver physiology and pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32917322
DOI: 10.1016/j.tjog.2020.07.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of genetic mutations in intrahepatic cholestasis of pregnancyPMID 32917322Read ↗

Whole-exome sequencing identifies novel mutations in ABC transporter genes associated with intrahepatic cholestasis of pregnancy disease: a case-control study.Semantic proximity Read ↗

ABCB4 gene mutations and single-nucleotide polymorphisms in women with intrahepatic cholestasis of pregnancySemantic proximity Read ↗

ABCB4 and ABCB11 mutations in intrahepatic cholestasis of pregnancy in an Italian population.Semantic proximity Read ↗

An expanded role for heterozygous mutations of ABCB4, ABCB11, ATP8B1, ABCC2 and TJP2 in intrahepatic cholestasis of pregnancySemantic proximity Read ↗

Whole-exome sequencing expands the roles of novel mutations of organic anion transporting polypeptide, ATP-binding cassette transporter, and receptor genes in intrahepatic cholestasis of pregnancySemantic proximity Read ↗

Genetic issues in ICPSemantic proximity Read ↗

Whole-exome sequencing reveals ANO8 as a genetic risk factor for intrahepatic cholestasis of pregnancySemantic proximity Read ↗

Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy.Semantic proximity Read ↗

The molecular genetics of intrahepatic cholestasis of pregnancySemantic proximity Read ↗

Review article: liver disease in adults with variants in the cholestasis-related genes ABCB11, ABCB4 and ATP8B1.Semantic proximity Read ↗

A comprehensive analysis of common genetic variation around six candidate loci for intrahepatic cholestasis of pregnancy.Semantic proximity Read ↗

Associations between ALDOB polymorphisms and intrahepatic cholestasis of pregnancy susceptibility in the Chinese Han population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.