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Article

Causal association between epilepsy and its DNA methylation profile and atrial fibrillation.

Heart rhythm - 1 Jun 2025

Zheng Zequn, Chen Haohao, Chen Yanbin, Tan Xuerui

Abstract excerpt

BACKGROUND: The "epileptic heart" concept is emerging, but the causal relationship between epilepsy and atrial fibrillation (AF) remains unclarified. OBJECTIVE: This study explores the genetic correlations and bidirectional causality between various epilepsy phenotypes and AF. METHODS: Genome-wide association study (GWAS) statistics for 10 epilepsy subtypes (29,944 cases, 52,538 controls) and AF (60,620 cases,...

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Topics

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Share to Atrial Fibrillation
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Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

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Source

Identifiers

PMID: 39260664
DOI: 10.1016/j.hrthm.2024.09.008

Genes

PLA2G5
SPPL2B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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