Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction.

doi:10.1038/s41588-022-01284-9

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Article

Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction.

Nature genetics - 1 Feb 2023

Miyazawa Kazuo, Ito Kaoru, Ito Masamichi, Zou Zhaonan, Kubota Masayuki, Nomura Seitaro, Matsunaga Hiroshi, Koyama Satoshi, Ieki Hirotaka, Akiyama Masato, Koike Yoshinao, Kurosawa Ryo, Yoshida Hiroki, Ozaki Kouichi, Onouchi Yoshihiro, Takahashi Atsushi, Matsuda Koichi, Murakami Yoshinori, Aburatani Hiroyuki, Kubo Michiaki, Momozawa Yukihide, Terao Chikashi, Oki Shinya, Akazawa Hiroshi, Kamatani Yoichiro, Komuro Issei

Abstract excerpt

Atrial fibrillation (AF) is a common cardiac arrhythmia resulting in increased risk of stroke. Despite highly heritable etiology, our understanding of the genetic architecture of AF remains incomplete. Here we performed a genome-wide association study in the Japanese population comprising 9,826 cases among 150,272 individuals and identified East Asian-specific rare variants associated with AF. A cross-ancestry...

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Identifiers

PMID: 36653681
DOI: 10.1038/s41588-022-01284-9
PMCID: PMC9925380

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