Article
Genome-wide DNA methylation analysis in permanent atrial fibrillation.
Molecular medicine reports - 1 Oct 2017
Zhao Guochang, Zhou Jian, Gao Jie, Liu Yan, Gu Song, Zhang Xitao, Su Pixiong
Abstract excerpt
Atrial fibrillation (AF) is a highly heterogeneous genetic disease; however, the pathogenesis of AF cannot be explained by genetic variants alone. DNA methylation is a heritable method of gene expression regulation, and may be a potential regulatory mechanism in AF. Therefore, in the present study, the genome‑wide DNA methylation pattern in cells derived from the left atrium of patients with permanent AF (n=7)...
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