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Article

Genetic Evidence for Causal Association Between Atrial Fibrillation and Dementia: A Mendelian Randomization Study.

Journal of the American Heart Association - 15 Aug 2023

Li Mingxiao, Jiang Chao, Lai Yiwei, Wang Yufeng, Zhao Manlin, Li Sitong, Peng Xiaodong, He Liu, Guo Xueyuan, Li Songnan, Liu Nian, Jiang Chenxi, Tang Ribo, Sang Caihua, Long Deyong, Du Xin, Dong Jianzeng, Ma Changsheng

Abstract excerpt

Background The knowledge gap regarding whether the correlation between atrial fibrillation (AF) and dementia in observational studies is causation or driven by other shared risk factors remains substantially unfilled. Methods and Results We performed a comprehensive 2-sample Mendelian randomization study to evaluate the causal effect of AF on overall dementia and its subtypes, including vascular dementia,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37548160
DOI: 10.1161/JAHA.123.029623
PMCID: PMC10492936

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