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Article

Generalized disequilibrium test for association in qualitative traits incorporating imprinting effects based on extended pedigrees.

BMC genetics - 16 Oct 2017

Li Jian-Long, Wang Peng, Fung Wing Kam, Zhou Ji-Yuan

Abstract excerpt

BACKGROUND: For dichotomous traits, the generalized disequilibrium test with the moment estimate of the variance (GDT-ME) is a powerful family-based association method. Genomic imprinting is an important epigenetic phenomenon and currently, there has been increasing interest of incorporating imprinting to improve the test power of association analysis. However, GDT-ME does not take imprinting effects into...

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Identifiers

PMID: 29037145
DOI: 10.1186/s12863-017-0560-0
PMCID: PMC5644153

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