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Article

The histone methyltransferase Mixed-lineage-leukemia-1 drives T cell phenotype via Notch signaling in diabetic tissue repair.

JCI insight - 27 Aug 2024

Melvin William J, Bauer Tyler M, Mangum Kevin D, Audu Christopher O, Shadiow James, Barrett Emily C, Joshi Amrita D, Moon Jadie Y, Bogle Rachael, Mazumder Purba, Wolf Sonya J, Kunke Steven L, Gudjonsson Johann E, Davis Frank M, Gallagher Katherine A

Abstract excerpt

Immune cell-mediated inflammation is important in normal tissue regeneration but can be pathologic in diabetic wounds. Limited literature exists on the role of CD4+ T cells in normal or diabetic wound repair; however, the imbalance of CD4+ Th17/Tregs has been found to promote inflammation in other diabetic tissues. Here, using human tissue and murine transgenic models, we identified that the histone...

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Share to CD4-Positive T-Lymphocytes
Share to Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Myeloid-Lymphoid Leukemia Protein

Share to Nuclear Receptor Subfamily 1, Group F, Member 3

Share to Receptors, Notch

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Source

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Identifiers

PMID: 39250432
DOI: 10.1172/jci.insight.179012
PMCID: PMC11463913

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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