Article
Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair.
JCI insight - 3 Sept 2020
Davis Frank M, Tsoi Lam C, Wasikowski Rachael, denDekker Aaron, Joshi Amrita, Wilke Carol, Deng Hongping, Wolf Sonya, Obi Andrea, Huang Steven, Billi Allison C, Robinson Scott, Lipinski Jay, Melvin William J, Audu Christopher O, Weidinger Stephan, Kunkel Steven L, Smith Andrew, Gudjonsson Johann E, Moore Bethany B, Gallagher Katherine A
Abstract excerpt
Macrophages are a primary immune cell involved in inflammation, and their cell plasticity allows for transition from an inflammatory to a reparative phenotype and is critical for normal tissue repair following injury. Evidence suggests that epigenetic alterations play a critical role in establishing macrophage phenotype and function during normal and pathologic wound repair. Here, we find in human and murine...
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