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Article

MALAT1: An Epigenetic Regulator of Inflammation in Diabetic Retinopathy

19 Apr 2018

Abstract excerpt

Despite possessing limited protein-coding potential, long non-coding RNAs (lncRNAs) have been implicated in a myriad of pathologic conditions. Most well documented in cancer, one prominent intergenic lncRNA known as MALAT1 is notorious for its role in impacting epigenetic mechanisms. In this study, we established a novel epigenetic paradigm for MALAT in diabetic retinopathy (DR) by employing siRNA-mediated MALAT1...

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PMID: 29695738
DOI: 10.1038/s41598-018-24907-w

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