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Multiplex imaging of localized prostate tumors reveals altered spatial organization of AR-positive cells in the microenvironment

3 Aug 2024

Abstract excerpt

Mapping the spatial interactions of cancer, immune, and stromal cell states presents novel opportunities for patient stratification and for advancing immunotherapy. While single-cell studies revealed significant molecular heterogeneity in prostate cancer cells, the impact of spatial stromal cell heterogeneity remains poorly understood. Here, we used cyclic immunofluorescent imaging on whole-tissue sections to...

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PMID: 39246442
DOI: 10.1016/j.isci.2024.110668

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