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CCDC181 is required for sperm flagellum biogenesis and male fertility in mice

1 Jan 2024

Abstract excerpt

The integrity of the sperm flagellum is essential for normal sperm function. Defects in the flagellum can lead to male infertility, however, the mechanisms underlying this relationship are largely unknown. CCDC181, a protein containing a coiled-coil domain, localizes on the sperm flagella and the basal parts of motile cilia. The roles of CCDC181 in flagellum biogenesis have remained elusive. In this study,...

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PMID: 39245650
DOI: 10.24272/j.issn.2095-8137.2024.075

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