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Article

LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse.

International journal of molecular sciences - 31 Jul 2022

Yin Yingying, Mu Wenyu, Yu Xiaochen, Wang Ziqi, Xu Ke, Wu Xinyue, Cai Yuling, Zhang Mingyu, Lu Gang, Chan Wai-Yee, Ma Jinlong, Huang Tao, Liu Hongbin

Abstract excerpt

The sperm flagellum is essential for male fertility. Multiple morphological abnormalities of the sperm flagella (MMAF) is a severe form of asthenoteratozoospermia. MMAF phenotypes are understood to result from pathogenic variants of genes from multiple families including AKAP, DANI, DNAH, RSPH, CCDC, CFAP, TTC, and LRRC, among others. The Leucine-rich repeat protein (LRRC) family includes two members reported to...

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Identifiers

PMID: 35955660
DOI: 10.3390/ijms23158525
PMCID: PMC9369233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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