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CCDC38 is required for sperm flagellum biogenesis and male fertility in mice

19 May 2022

Abstract excerpt

The sperm flagellum is essential for male fertility, and defects in flagellum biogenesis are associated with male infertility. Deficiency of coiled-coil domain-containing (CCDC) 42 (CCDC42) is specifically associated with malformation of mouse sperm flagella. Here, we find that the testis-specific protein CCDC38 interacts with CCDC42, localizing on the manchette and sperm tail during spermiogenesis. Inactivation...

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PMID: 35587122
DOI: 10.1242/dev.200516

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CCDC38 is required for sperm flagellum biogenesis and male fertility in micePMID 35587122Read ↗

<i>Ccdc38</i> is required for sperm flagellum biogenesis and male fertility in mouseSemantic proximity Read ↗

CCDC181 is required for sperm flagellum biogenesis and male fertility in miceSemantic proximity Read ↗

Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in miceSemantic proximity Read ↗

CCDC189 affects sperm flagellum formation by interacting with CABCOCO1Semantic proximity Read ↗

CCDC42 Localizes to Manchette, HTCA and Tail and Interacts With ODF1 and ODF2 in the Formation of the Male Germ Cell CytoskeletonSemantic proximity Read ↗

CCDC146 is required for sperm flagellum biogenesis and male fertility in miceSemantic proximity Read ↗

CCDC28A deficiency causes head-tail coupling defects and immotility in murine spermatozoaSemantic proximity Read ↗

Coiled-coil domain containing 42 ( Ccdc 42) is necessary for proper sperm development and male fertility in the mouseSemantic proximity Read ↗

Homozygous mutations in CCDC34 cause male infertility with oligoasthenoteratozoospermia in humans and mice.Semantic proximity Read ↗

CFAP58 is involved in the sperm head shaping and flagellogenesis of cattle and miceSemantic proximity Read ↗

Intraflagellar transporter protein 140 (IFT140), a component of IFT‐A complex, is essential for male fertility and spermiogenesis in miceSemantic proximity Read ↗

Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouseSemantic proximity Read ↗

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