Article
Survival in Patients with Uveal Melanoma Is Linked to Genetic Variation at HERC2 Single Nucleotide Polymorphism rs12913832.
Ophthalmology - 1 Mar 2025
Gelmi Maria Chiara, Houtzagers Laurien E, Wierenga Annemijn P A, Versluis Mieke, Heijmans Bastiaan T, Luyten Gregorius P M, de Knijff Peter, Te Raa Marije, de Leeuw Rick H, Jager Martine J
Abstract excerpt
PURPOSE: Uveal melanoma (UM) is a rare disease, with the highest incidence in people with fair skin and light eyes. Eye color is largely genetically determined and is defined by a set of single nucleotide polymorphisms (SNPs). We set out to determine whether we could identify a SNP related to prognosis. DESIGN: We sequenced DNA from peripheral blood mononuclear cells of 392 patients with UM and obtained the...
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