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A ubiquitin-mediated post-translational degradation of Cyp51A contributes to a novel azole resistance mode in Aspergillus fumigatus.

Microbiological research - 1 Dec 2024

Zhu Guoxing, Fu Mengjuan, Zhang Yuanwei, Lu Ling

Abstract excerpt

The airborne fungus Aspergillus fumigatus is a major pathogen that poses a serious health threat to humans by causing aspergillosis. Azole antifungals inhibit sterol 14-demethylase (encoded by cyp51A), an enzyme crucial for fungal cell survival. However, the most common mechanism of azole resistance in A. fumigatus is associated with the mutations in cyp51A and tandem repeats in its promoter, leading to reduced...

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PMID: 39244806
DOI: 10.1016/j.micres.2024.127891

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