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Article

Does HLA explain the high incidence of childhood-onset type 1 diabetes in the Canary Islands? The role of Asp57 DQB1 molecules.

BMC pediatrics - 6 Sept 2024

Nóvoa-Medina Yeray, Marcelino-Rodriguez Itahisa, Suárez Nicolás M, Barreiro-Bautista Marta, Rivas-García Eva, Sánchez-Alonso Santiago, González-Martínez Gema, Quinteiro-González Sofía, Domínguez Ángela, Cabrera María, López Sara, Pavlovic Svetlana, Flores Carlos, Wägner Ana M

Abstract excerpt

The Canary Islands inhabitants, a recently admixed population with significant North African genetic influence, has the highest incidence of childhood-onset type 1 diabetes (T1D) in Spain and one of the highest in Europe. HLA accounts for half of the genetic risk of T1D. AIMS: To characterize the classical HLA-DRB1 and HLA-DQB1 alleles in children from Gran Canaria with and without T1D. METHODS: We analyzed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39243072
DOI: 10.1186/s12887-024-04983-w
PMCID: PMC11378579

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