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Association between HLA Class II Alleles/Haplotypes and Genomic Ancestry in Brazilian Patients with Type 1 Diabetes: A Nationwide Exploratory Study.

Genes - 27 Apr 2023

Gomes Marília Brito, Rodrigues Vandilson, Santos Deborah Conte, Bôas Paulo Ricardo Villas, Silva Dayse A, de Sousa Azulay Rossana Santiago, Dib Sergio Atala, Pavin Elizabeth João, Fernandes Virgínia Oliveira, Montenegro Junior Renan Magalhães, Felicio João Soares, Réa Rosangela, Negrato Carlos Antonio, Porto Luís Cristóvão

Abstract excerpt

We aimed to identify HLA-DRB1, -DQA1, and -DQB1 alleles/haplotypes associated with European, African, or Native American genomic ancestry (GA) in admixed Brazilian patients with type 1 diabetes (T1D). This exploratory nationwide study enrolled 1599 participants. GA percentage was inferred using a panel of 46 ancestry informative marker-insertion/deletion. Receiver operating characteristic curve analysis (ROC) was...

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Identifiers

PMID: 37239351
DOI: 10.3390/genes14050991
PMCID: PMC10218425

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