Article
Targeted analysis of genomic regions enriched in African ancestry reveals novel classical HLA alleles associated with asthma in Southwestern Europeans.
Scientific reports - 8 Dec 2021
Suarez-Pajes Eva, Díaz-García Claudio, Rodríguez-Pérez Héctor, Lorenzo-Salazar Jose M, Marcelino-Rodríguez Itahisa, Corrales Almudena, Zheng Xiuwen, Callero Ariel, Perez-Rodriguez Eva, Garcia-Robaina Jose C, González-Montelongo Rafaela, Flores Carlos, Guillen-Guio Beatriz
Abstract excerpt
Despite asthma has a considerable genetic component, an important proportion of genetic risks remain unknown, especially for non-European populations. Canary Islanders have the largest African genetic ancestry observed among Southwestern Europeans and the highest asthma prevalence in Spain. Here we examined broad chromosomal regions previously associated with an excess of African genetic ancestry in Canary...
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