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MPAD: A Database for Binding Affinity of Membrane Protein-protein Complexes and their Mutants.

Journal of molecular biology - 15 Jul 2023

Ridha Fathima, Kulandaisamy A, Michael Gromiha M

Abstract excerpt

Membrane protein complexes are crucial for a large variety of biological functions which are mainly dictated by their binding affinity. Due to the intricate nature of their structure, however, the binding affinity of membrane proteins is less explored compared to globular proteins. Mutations in these complexes affect their binding affinity, as well as impair critical functions, and may lead to diseases. Although...

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PMID: 36309134
DOI: 10.1016/j.jmb.2022.167870

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