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Article

Unveiling inter-embryo variability in spindle length over time: Towards quantitative phenotype analysis.

PLoS computational biology - 1 Sept 2024

Le Cunff Yann, Chesneau Laurent, Pastezeur Sylvain, Pinson Xavier, Soler Nina, Fairbrass Danielle, Mercat Benjamin, Rodriguez-Garcia Ruddi, Alayan Zahraa, Abdouni Ahmed, de Neidhardt Gary, Costes Valentin, Anjubault Mélodie, Bouvrais Hélène, Héligon Christophe, Pécréaux Jacques

Abstract excerpt

How can inter-individual variability be quantified? Measuring many features per experiment raises the question of choosing them to recapitulate high-dimensional data. Tackling this challenge on spindle elongation phenotypes, we showed that only three typical elongation patterns describe spindle elongation in C. elegans one-cell embryo. These archetypes, automatically extracted from the experimental data using...

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Identifiers

PMID: 39236069
DOI: 10.1371/journal.pcbi.1012330
PMCID: PMC11376571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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