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Article

Chromosome X-wide association study in multiple system atrophy identifies sex-differential risk loci.

Brain : a journal of neurology - 7 Sept 2026

Ray Anindita, Chia Ruth, Rasheed Memoona, Bayram Ece, Dickson Dennis W, Traynor Bryan J, Gibbs J Raphael, Dalgard Clifton L, Ross Owen A, Houlden Henry, Scholz Sonja W

Abstract excerpt

The human X chromosome accounts for ∼5% of the genome. Despite its size, the role of X-chromosomal variants in human diseases is not well understood, mainly due to its distinct inheritance pattern and the frequent omission of sex chromosomes from genome-wide association studies. This study used whole-genome sequencing data from 888 multiple system atrophy (MSA) cases and 7128 controls to perform an...

Read the complete abstract on PubMed

Topics

Humans
Genome-Wide Association Study
Chromosomes, Human, X
Female
Male
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Multiple System Atrophy

Polymorphism, Single Nucleotide

Sex Characteristics

Source

Open in PubMed Open full text

Identifiers

PMID: 41684229
DOI: 10.1093/brain/awag062
PMCID: PMC13548872

Genes

FAM3A
PLXNA3
TBL1X

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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