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[Causal relationship between thyroid dysfunction and sepsis: a bidirectional two-sample Mendelian randomization].

Zhonghua wei zhong bing ji jiu yi xue - 1 Jul 2024

Yuan Jiawen, Wang Dexiang, Hang Yuhao, Lu Qinyun, Wang Jian, Lu Jun, Cheng Lu

Abstract excerpt

OBJECTIVE: To explore the causal relationship between thyroid dysfunction and sepsis based on the bidirectional two-sample Mendelian randomization (MR) method. METHODS: The genome-wide association study (GWAS) dataset were selected to screen single nucleotide polymorphisms (SNP) associated with thyroid dysfunction as instrumental variable (IV) for genetic variation, using hypothyroidism and hyperthyroidism as...

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Genome-Wide Association Study
Hyperthyroidism
Hypothyroidism
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thyroid Diseases

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PMID: 39223889
DOI: 10.3760/cma.j.cn121430-20240226-00161

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