Causal associations of gastroesophageal reflux disease with sepsis and sepsis mortality within 28 days: A bidirectional 2-sample Mendelian randomization study.

Abstract excerpt

Previous studies have demonstrated a potential correlation between gastroesophageal reflux disease (GERD) and sepsis. However, the causal association between GERD and sepsis remains unclear. We performed a bidirectional 2-sample Mendelian randomization (MR) analysis to investigate the causal associations of GERD with sepsis and sepsis mortality within 28 days. The inverse variance weighted method was used as a...

Topics

• Gastroesophageal Reflux
• Humans
• Sepsis
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide