Article
Absence of ATG9A and synaptophysin demixing on Rab5 mutation-induced giant endosomes.
Molecular brain - 2 Sept 2024
Choi Jiyoung, Wu Yumei, Park Daehun
Abstract excerpt
ATG9A is the only integral membrane protein among core autophagy-related (ATG) proteins. We previously found that ATG9A does not co-assemble into synaptophysin-positive vesicles, but rather, localizes to a distinct pool of vesicles within synapsin condensates in both fibroblasts and nerve terminals. The endocytic origin of these vesicles further suggests the existence of different intracellular sorting or...
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