Article
Unsupervised discovery of phenotype-specific multi-omics networks.
Bioinformatics (Oxford, England) - 1 Nov 2019
Shi W Jenny, Zhuang Yonghua, Russell Pamela H, Hobbs Brian D, Parker Margaret M, Castaldi Peter J, Rudra Pratyaydipta, Vestal Brian, Hersh Craig P, Saba Laura M, Kechris Katerina
Abstract excerpt
MOTIVATION: Complex diseases often involve a wide spectrum of phenotypic traits. Better understanding of the biological mechanisms relevant to each trait promotes understanding of the etiology of the disease and the potential for targeted and effective treatment plans. There have been many efforts towards omics data integration and network reconstruction, but limited work has examined the incorporation of...
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