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Comparing GBA1-Parkinson's disease and idiopathic Parkinson's disease: α-Synuclein oligomers and synaptic density as biomarkers in the skin biopsy.

Brain pathology (Zurich, Switzerland) - 1 Nov 2024

Mazzetti Samanta, Contaldi Elena, Basellini Milo Jarno, Novello Claudia, Calogero Alessandra Maria, Straniero Letizia, Garrì Federica, Ferri Valentina, Calandrella Daniela, Del Sorbo Francesca, Asselta Rosanna, Cereda Emanuele, Cappelletti Graziella, Isaias Ioannis Ugo, Pezzoli Gianni

Abstract excerpt

The main genetic risk factors for Parkinson's disease (PD) are presently represented by variants in GBA1 gene encoding for the β-glucocerebrosidase (GCase). Searching for a peripheral biomarker that can be used for selecting and monitoring patients in clinical trials targeting GBA1-associated PD (GBA1-PD) is a current challenge. We previously demonstrated that α-synuclein oligomers expressed as proximity ligation...

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Identifiers

PMID: 39219308
DOI: 10.1111/bpa.13284
PMCID: PMC11483590

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