Article
The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse.
Pharmacogenetics - 1 Dec 2004
Lin Zhicheng, Walther Donna, Yu Xiao-Ying, Drgon Tomas, Uhl George R
Abstract excerpt
OBJECTIVE AND METHODS: 5-Hydroxytryptamine (serotonin) receptor 2B (HTR2B) is involved in brain development. Although expressed in the human brain, HTR2B has not been investigated much for its role in higher brain functions. Here we describe a genome-scan with 391 simple sequence repeat markers in 300 Caucasians, identifying HTR2B gene as a candidate for drug abuse vulnerability. RESULTS: From DNA re-sequencing...
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