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Article

Human single-domain neutralizing intrabodies directed against Etk kinase: a novel approach to impair cellular transformation

1 Nov 2005

Abstract excerpt

Etk, the 70-kDa member of the Tec family of nonreceptor protein tyrosine kinases, is expressed in a variety of hematopoietic, epithelial, and endothelial cells and was shown to be involved in several cellular processes, including proliferation, differentiation, and motility. In this study, we describe a novel approach using a human single-domain antibody phage display library for the generation of intrabodies...

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PMID: 16276002
DOI: 10.1158/1535-7163.mct-05-0174

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