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Article

A general strategy for highly sensitive analysis of genetic biomarkers at single-base resolution with ligase-based isothermally exponential amplification.

Talanta - 15 May 2020

Wang Hui, Wang Honghong, Sun Yuanyuan, Liu Xiaoling, Liu Ye, Wang Chengli, Zhang Pengbo, Li Zhengping

Abstract excerpt

Robust, reliable, and sensitively quantitative detection of genetic biomarkers at single-base resolution has the potential to revolutionize medical diagnostics, especially for precision medicine. Here, taking the advantages of the high specificity of ligase reaction and the powerful amplification features of the isothermally exponential amplification, we have demonstrated a novel methodology to sensitively...

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PMID: 32113533
DOI: 10.1016/j.talanta.2020.120754

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