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Article

miRNAs in chronic myeloid leukemia: small molecules, essential function

13 Oct 2016

Abstract excerpt

Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with clonal expansion of cancerous bone marrow stem cells. Tyrosine kinase inhibitors (TKIs) targeting Bcr-Abl oncoprotein are the first-line therapy for most CML patients, however, some are unresponsive to it or develop resistance. Recently, microRNAs (miRNAs) have been implicated in the progression of CML and the development of TKI...

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PMID: 27736267
DOI: 10.1080/10428194.2016.1243676

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