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Article

CaV1.1 voltage-sensing domain III exclusively controls skeletal muscle excitation-contraction coupling.

Nature communications - 28 Aug 2024

Pelizzari Simone, Heiss Martin C, Fernández-Quintero Monica L, El Ghaleb Yousra, Liedl Klaus R, Tuluc Petronel, Campiglio Marta, Flucher Bernhard E

Abstract excerpt

Skeletal muscle contractions are initiated by action potentials, which are sensed by the voltage-gated calcium channel (CaV1.1) and are conformationally coupled to calcium release from intracellular stores. Notably, CaV1.1 contains four separate voltage-sensing domains (VSDs), which activate channel gating and excitation-contraction (EC-) coupling at different voltages and with distinct kinetics. Here we show...

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Identifiers

PMID: 39198449
DOI: 10.1038/s41467-024-51809-5
PMCID: PMC11358481

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