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Article

Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants

20 Jun 2019

Abstract excerpt

Background: Truncating variants in the Titin gene (TTNtvs) are common in individuals with idiopathic dilated cardiomyopathy (DCM). However, a comprehensive genomics-first evaluation of the impact of TTNtvs in different clinical contexts, and the evaluation of modifiers such as genetic ancestry, has not been performed. Methods: We reviewed whole exome sequence data for >71 000 individuals (61 040 from the...

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PMID: 31216868
DOI: 10.1161/circulationaha.119.039573

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