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Article

Amino acid metabolism in glioma: in vivo MR-spectroscopic detection of alanine as a potential biomarker of poor survival in glioma patients.

Journal of neuro-oncology - 1 Nov 2024

Alcicek Seyma, Pilatus Ulrich, Manzhurtsev Andrei, Weber Katharina J, Ronellenfitsch Michael W, Steinbach Joachim P, Hattingen Elke, Wenger Katharina J

Abstract excerpt

PURPOSE: Reprogramming of amino acid metabolism is relevant for initiating and fueling tumor formation and growth. Therefore, there has been growing interest in anticancer therapies targeting amino acid metabolism. While developing personalized therapeutic approaches to glioma, in vivo proton magnetic resonance spectroscopy (MRS) is a valuable tool for non-invasive monitoring of tumor metabolism. Here, we...

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Identifiers

PMID: 39192067
DOI: 10.1007/s11060-024-04803-2
PMCID: PMC11538230

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