Non‐invasive detection of glycine as a biomarker of malignancy in childhood brain tumours using <i>in‐vivo</i>¹H MRS at 1.5 Tesla confirmed by <i>ex‐vivo</i> high‐resolution magic‐angle spinning NMR

Abstract excerpt

Management of brain tumours in children would benefit from improved non-invasive diagnosis, characterisation and prognostic biomarkers. Metabolite profiles derived from in-vivo MRS have been shown to provide such information. Studies indicate that using optimum a priori information on metabolite contents in the construction of linear combination (LC) models of MR spectra leads to improved metabolite profile...

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