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Article

Programmed cell death evasion in BRAF V600E-driven primary CNS tumors and thyroid cancer brain metastases.

Frontiers in neurology - 1 Jan 2026

Jin Tong, Lv Yuanshi, Yang Qiushi, Zhang Rui, Jin Hui

Abstract excerpt

BRAF V600E occurs in selected primary central nervous system (CNS) tumors and in a subset of thyroid cancers that can metastasize to the brain, but the shared alteration does not make these diseases biologically equivalent. This Mini Review examines programmed cell death evasion in pleomorphic xanthoastrocytoma and ganglioglioma, with selected molecular and clinical comparisons involving epithelioid glioblastoma,...

Read the complete abstract on PubMed

Topics

Humans
Proto-Oncogene Proteins B-raf
Brain Neoplasms
Thyroid Neoplasms
Animals
Central Nervous System Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Apoptosis

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42769885
DOI: 10.3389/fneur.2026.1921351
PMCID: PMC13591381

Genes

BRAF
DHODH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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