Article
De Novo Genome Assemblies From Two Indigenous Americans from Arizona Identify New Polymorphisms in Non-Reference Sequences.
Genome biology and evolution - 3 Sept 2024
Köroğlu Çiğdem, Chen Peng, Traurig Michael, Altok Serdar, Bogardus Clifton, Baier Leslie J
Abstract excerpt
There is a collective push to diversify human genetic studies by including underrepresented populations. However, analyzing DNA sequence reads involves the initial step of aligning the reads to the GRCh38/hg38 reference genome which is inadequate for non-European ancestries. In this study, using long-read sequencing technology, we constructed de novo genome assemblies from two indigenous Americans from Arizona...
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