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<i>De novo</i> genome assemblies from two Indigenous Americans from Arizona identify new polymorphisms in non-reference sequences

2023-10-25

Abstract excerpt

<h4>ABSTRACT</h4> There is a collective push to diversify human genetic studies by including underrepresented populations. However, analyzing DNA sequence reads involves the initial step of aligning the reads to the GRCh38/hg38 reference genome which is inadequate for non-European ancestries. To help address this issue, we created a modified hg38 reference map using de novo sequence assemblies from Indigenous Am...

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Literature Corpus work: a5433e8d-03d9-5abf-bcc0-5557b007fa22
DOI: 10.1101/2023.10.23.563520

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