Article
Integration of genomic and pharmacokinetic data to predict clinical outcomes in HIV-associated cryptococcal meningitis.
mBio - 16 Oct 2024
Stott Katharine E, Mohabir Jason T, Bowers Katharine, Tenor Jennifer L, Toffaletti Dena L, Unsworth Jennifer, Jimenez-Valverde Ana, Ahmadu Ajisa, Moyo Melanie, Gondwe Ebbie, Chimang'anga Wezi, Chasweka Madalitso, Lawrence David S, Jarvis Joseph N, Harrison Tom, Hope William, Lalloo David G, Mwandumba Henry C, Perfect John R, Cuomo Christina A
Abstract excerpt
Cryptococcal meningitis causes an estimated 112,000 global deaths per annum. Genomic and phenotypic features of the infecting strain of Cryptococcus spp. have been associated with outcomes from cryptococcal meningitis. Additionally, population-level pharmacokinetic variability is well documented in these patient cohorts. The relative contribution of these factors to clinical outcomes is unknown. Based in Malawi,...
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