Article

Low-Strength Type I Interferon Signaling Promotes CAR T-Cell Treatment Efficacy

2025-05-17

Abstract excerpt

<h4>ABSTRACT</h4> CD19-directed chimeric antigen receptor (CAR) T-cell therapy has significantly advanced the treatment landscape for relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL). However, up to 60% of patients do not achieve a complete response. To uncover determinants of therapeutic efficacy, we analyzed the infusion products of eight r/r DLBCL patients with distinct clinical responses to axica...

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Literature Corpus work: c62ec04e-954e-5dde-b316-83c35e060ab5
DOI: 10.1101/2025.05.13.653878

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