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Article

A machine learning enhanced EMS mutagenesis probability map for efficient identification of causal mutations in Caenorhabditis elegans.

PLoS genetics - 1 Aug 2024

Guo Zhengyang, Wang Shimin, Wang Yang, Wang Zi, Ou Guangshuo

Abstract excerpt

Chemical mutagenesis-driven forward genetic screens are pivotal in unveiling gene functions, yet identifying causal mutations behind phenotypes remains laborious, hindering their high-throughput application. Here, we reveal a non-uniform mutation rate caused by Ethyl Methane Sulfonate (EMS) mutagenesis in the C. elegans genome, indicating that mutation frequency is influenced by proximate sequence context and...

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PMID: 39186782
DOI: 10.1371/journal.pgen.1011377
PMCID: PMC11379379

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